FceRII/CD23 Is Expressed in Parkinson’s Disease and Induces, In Vitro, Production of Nitric Oxide and Tumor Necrosis Factor-a in Glial Cells
نویسندگان
چکیده
1Institut National de la Santé et de la Recherche Médicale, Unité 289, Mécanismes et Conséquences de la Mort Neuronale, Hôpital de la Salpêtrière, F-75013 Paris, France, 2Laboratoire “Virus, Neurone et Immunité,” Unité de Formation et de Recherche Kremlin Bicêtre, F-94276 Le Kremlin-Bicêtre Cedex, France, 3Centre National de la Recherche Scientifique, Unité de Recherche Associée 625, Laboratoire d’Immunologie Cellulaire et Tissulaire, Hôpital de la Salpêtrière, F-75013 Paris, France, and 4Oxykine Therapeutics, F-75116 Paris, France
منابع مشابه
Involvement of Cyclic AMP and Nitric Oxide in Immunoglobulin E - dependent Activation of FcERII / CD 23 + Normal Human Keratinocytes
Epidermal keratinocytes (EK) are exposed to multiple inflammatory stimuli and paracrine factors secreted by various dermal cells (lymphocytes, mast cells, macrophages, fibroblasts) during wounding, cutaneous allergy, and infections. We have previously demonstrated that after stimulation with interleukin 4 or interferon-y, human EK express the low-affinity receptor for IgE (FceRII/CD23) on their...
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The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...
متن کاملAGE proteins as a causative factor in Alzheimer's Disease
The reaction between reducing sugars and protein free amines, known as the Maillar reaction results in the formation of advanced glycation endproducts (AGEs). AGE modification changes the structure of proteins to amyloid cross-beta structure. These protein structures can activate receptors known as RAGE on glial cells (microglia and astrocytes), and induce the expression of inducible nitric oxi...
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Background: Neuroinflammation, as a major outcome of microglia activation, is an important factor for progression of neurodegenerative disorders including Alzheimer's disease and Parkinson's disease. Microglial cells, as the first-line defense in the central nervous system, act as a source of neurotoxic factors such as nitric oxide (NO), a free radical which is involved in neuronal cell death. ...
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Recent studies have established that sex hormones directly or indirectly affect T and B cells and macrophages by manipulating the production of cytokines. In this study the possibility of the effect of 5a-DHT on macrophage (MΦ) nitric oxide (NO) release via interleukin-l, 6 (lL-1β, IL-6) or tumor necrosis factor-a (TNFα) was investigated. The endogenous cytokines IL-1β, IL-6 and TNF-α were ...
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